Applying Lasers to Life Threatening Medical & National Security Challenges

Leveraging ultrafast lasers to solve challenges in medicine, homeland security, and energy

Laser technology already plays a role in devices like barcode scanners in the local grocery store and DVD players at home. Ultrafast lasers, producing pulses as short as a few millionth of a billionth of a second, are just now entering applications such as corrective eye surgery and are being used to manufacture smart phones. Prof. Dantus, University Distinguished Professor of Chemistry and Physics at Michigan State University, and his research team strive to understand and control light-matter interactions using ultrafast lasers. The fundamental findings are then leveraged to solve practical challenges such as trace detection (e.g. toxins in food or explosives) and biomedical imaging (e.g. cancer detection).

A creative scientist and inventor, Prof. Dantus co-authored 20 of the first papers on femtochemistry which earned his Ph.D. advisor, Prof. Ahmed Zewail, the Nobel Prize in 1999. Since then, his research in the field has led to 24 patents and the invention of a technology to characterize and shape laser pulses in use at the most advanced ultrafast laser laboratories around the world today.
Current research includes:

  • Improving optical methods for cancer detection: Leveraging ultrafast lasers to sense chemicals present in cancer and perform a “bladeless” optical biopsy able to diagnose as well as kill cancer cells.
  • Optical methods to detect explosives: Leveraging molecule-specific laser sensing technology to detect explosives, which could be used to tighten airport security or protect roadsides.
  • Understanding and controlling how molecules capture energy from light: Exploring the molecular parameters required to make an artificial device that could harness solar energy more efficiently.


Prof. Dantus has pioneered the use of spectrally and temporally shaped ultrafast pulses as photonic reagents to probe molecular properties and control chemical reactions as well as for practical applications such as biomedical imaging, proteomics and standoff detection of explosives. His contributions range from discovery of nonlinear optical properties and processes, invention of laser optimization instruments, and development of theory to simulate and predict the interaction of molecules with shaped laser beams. Prof. Dantus’s development of an instrument capable of automated laser pulse compression is enabling research around the world as well as novel fiber laser designs. Prof. Dantus is a Fellow of the National Academy of Inventors, The American Physical Society and The Optical Society of America.

Prof. Dantus received his B.A. and M.A. degrees in Chemistry from Brandeis University where he attended from 1982-1985. He received his Ph.D. in 1991 from Caltech where he worked with A. H. Zewail on the development of Femtosecond Transition State Spectroscopy, now known as Femtochemistry (1999 Chemistry Nobel Prize to Zewail). Prof. Dantus worked from 1991 to 1993 on the development of Ultrafast Electron Diffraction and published 20 articles with Zewail during 1986 and 1993. Prof. Dantus has over 200 publications and was named Inventor of the Year by Michigan State University in 2013 given his 43 invention disclosures and 22 issued patents. Prof. Dantus regularly collaborates with different branches of the DoD and was invited to DARPA’s Scientist Helping America, Arbitrary Waveform Generation, and Program for Ultrafast Laser Science workshops.

In 2012, Prof. Dantus was invited to speak on the future of Quantum Control for the NRC Committee of Atomic, Molecular and Optical Science. Prof. Dantus has founded two companies: KTM Industries, a company that manufactures biodegradable packing materials, and Biophotonic Solutions, the company that is commercializing automated femtosecond pulse compression. He serves as Chairman and CTO and is also the Director of Research and Development of Total Power Inc., for which he formulated a biodegradable fuel additive for the mining industry.

Since he was ten years old, Prof. Dantus wanted to be a scientist and an inventor. At the same time, he started a rock collection. At age sixteen, he saw a laser for the first time and since then he has devoted his time and energy to work on lasers and chemistry. His main source of motivation is to make a difference; Prof. Dantus works at times on fundamental research that has yet to find application and on improving the laser sources themselves.

Outside of his research, Prof. Dantus continues to collect rocks and enjoys outdoor sports activities like tennis, swimming, water skiing and snow skiing.

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Investigating the Role of Human Serum Albumin Protein Pocket on the Excited State Dynamics of Indocyanine Green Using Shaped...


Vortices in the wake of a femtosecond laser filament


Ultrafast Temporal Shaping Is Coming of Age


Real-time single-shot measurement and correction of pulse phase and amplitude for ultrafast lasers


Ultrafast Ionization and Fragmentation: From Small Molecules to Proteomic Analysis


Standoff explosives trace detection and imaging by selective stimulated Raman scattering


Multimodal microscopy with sub-30 fs Yb fiber laser oscillator



Inventor of the Year Award, 2013

Michigan State University

CLEO/Laser Focus World Innovation Award Winner, 2012

Camille Dreyfus Teacher-Scholar Award, 1998

Alfred P. Sloan Research Fellow, 1998

Packard Fellowship for Science and Engineering, 1995

Beckman Young Investigator Award, 1995

Milton and Francis Clauser Doctoral Prize, 1991

California Institute of Technology


U.S. Patent No. 9,048,632: "Ultrafast laser apparatus"

U.S. Patent No. 9,018,562: "Laser material processing system"

U.S. Patent No. 8,861,075: "Laser amplification system"

U.S. Patent No. 8,675,699: "Laser pulse synthesis system"

U.S. Patent No. 8,633,437: "Ultra-fast laser system (Raman and Remote Sensing)"

U.S. Patent No. 8,630,322: "Laser system for output manipulation (MIIPS 3)"

U.S. Patent No. 8,618,470: "Laser based identification of molecular characteristics (enantiomer detection)"